BPC-157

BPC-157 is considered one of the most effective peptides on the market for having a positive effect on injuries and assisting athletes to recover faster after intense training. Isolated from human gastric juice it enhances the healing properties of Human Growth Hormone (HGH).

BPC-157 (also known as PL 14736) is a pentadecapeptide, which is composed of 15 amino acids. It was discovered and isolated from human gastric juice. Research has shown that BPC 157 can strengthen the brain-gut connection; thereby having a positive effect on a number of functions in the body, such as strengthening the immune system and helping athletes recover from training sessions and injuries quicker. [1]

BPC-157 benefits include;

  • Quicker Recovery
  • Injury Treatment

BPC-157 History

BPC-157 was discovered at The Pharmacology Institute in Zagreb, Croatia in the early 1990’s and early research showed that it is highly effective in treating pathological, as well as chronic, conditions. [2]

Human Growth Hormone (HGH) is important for recovery and repair as it stimulates cell growth and cell regeneration. Research at Chang Gung University in Taiwan found that BPC-157 enhanced the healing properties of growth hormone. [3]

BPC-157 Benefits

Injuries to muscles, tendons, ligaments and other soft connective tissue are one of the major problems facing today’s athletes. Research at Umeå University in Sweden found that injury incidence in weightlifting was 2.4–3.3 injuries per 1000 hours of training. [4]

BPC157 Shoulder InjuryFurthermore, research has shown that more intense and technical types of weightlifting, like CrossFit, Olympic weightlifting, and powerlifting not surprisingly has a higher injury rate compared with bodybuilding. [5]

Most training injuries aren’t caused by training too intensely, but rather by failing to recover fully from previous workouts. This generally leads to “repetitive stress injuries,” that over time can lead to major injuries such as lower back pain, shoulder tears or ligament damage to the knees.

Aside from eating a balanced diet and supplementation, there are other factors which are important to include as part of an effective injury prevention and treatment protocol.

There has been much debate and focus over the last ten years on the importance of warming up and stretching the body before a training session to minimize your risk for injuries.  Proper protective equipment is also sometimes controversial.  However, research at The University of Alabama has shown that warming up and stretching 15 minutes before training will reduce your susceptibility to injuries. [6]

Sleep is an anabolic state, which is when key hormones such as Human Growth Hormone (HGH) are secreted. HGH promotes the growth, maintenance and repair of muscles and bones while you sleep.

Research shows that sleeping less than 8 hours for athletes can increase their injury risk by 1.7x, compared to those who get 8 or more hours. [7]

Furthermore, research at The University of Toronto in Canada has shown that 8 hours of sleep deprivation suppresses MyoD protein levels, which plays an important role in muscle growth and recovery, for up to 7 days. [8]

BPC157 Shoulder Pain

When it comes to supplementation, BPC-157 truly shines in this area. One of the key attributes of BPC-157 is its influence on a specific protein within the body called VEGFR2. Research has shown that when BPC-157 is introduced, the presence of VEGFR2 increases in cells. [9] VEGFR2 role is to regulate the development and homeostasis of blood and lymphatic vessels.

It also has a positive effect on connective tissue as it is known to speed up the growth and spread of fibroblasts, which are found in connective tissue and play an integral role in the formation of collagen. Research has shown that BPC 157 is effective at collagen reformation following surgery. [10]

Research has also shown that BPC-157 can both increase the rate and the frequency of recovery from damage to tendons [11] and ligaments [12], which are the most damaged tissues in the body as a result of intense training over prolonged periods of time.

BPC157 Tendon Damage

BPC-157 Side effects

No adverse or negative reactions were reported in trials conducted on human beings.

BPC-157 Dosage

*Popularly Recommended Dosing Guidelines for BPC-157

The recommended dose is 100-250 mcg per day, and users have shown results with no side effects with doses over 500 mcg. It is always recommended to start with a lower and adjust accordingly depending on the response.

Final Thoughts

Compared to steroids and testosterone, which offer users a faster burn regarding results, peptides like BPC-157 offers more of a medium burn, though without the potentially uncomfortable side effects that come with the former. This is why if your goal is to increase muscle mass, burn body fat, and improve muscle recovery then peptides are the best option.

Disclaimer: Peptide Hormones are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.

References

  1. Predrag Sikiric,1,* Sven Seiwerth,1 Rudolf Rucman,1 Danijela Kolenc,1 Lovorka Batelja Vuletic,1 Domagoj Drmic,1 Tihomir Grgic,1 Sanja Strbe,1 Goran Zukanovic,1 Dalibor Crvenkovic,1 Goran Madzarac,1 Iva Rukavina,1 Mario Sucic,1 Marko Baric,1 Neven Starcevic,1 Zoran Krstonijevic,1 Martina Lovric Bencic,1 Igor Filipcic,1 Dinko Stancic Rokotov,1 and Josipa Vlainic2 Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/ Accessed on 7 October 2018
  2. Sikirić P1, Petek M, Rucman R, Seiwerth S, Grabarević Z, Rotkvić I, Turković B, Jagić V, Mildner B, Duvnjak M, et al. A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC. https://www.ncbi.nlm.nih.gov/pubmed/8298609 Accessed on 7 October 2018
  3. Chang CH1, Tsai WC2, Hsu YH3, Pang JH4. Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. https://www.ncbi.nlm.nih.gov/pubmed/25415472 Accessed on 7 October 2018
  4. Ulrika Aasa1,2, Ivar Svartholm1, Fredrik Andersson1, Lars Berglund1,2 Injuries among weightlifters and powerlifters: a systematic review https://bjsm.bmj.com/content/51/4/211 Accessed on 7 October 2018
  5. Keogh JW1,2,3, Winwood PW4,5. The Epidemiology of Injuries Across the Weight-Training Sports. https://www.ncbi.nlm.nih.gov/pubmed/27328853 Accessed on 7 October 2018
  6. Woods K1, Bishop P, Jones E. Warm-up and stretching in the prevention of muscular injury. https://www.ncbi.nlm.nih.gov/pubmed/18027995 Accessed on 7 October 2018
  7. Milewski MD1, Skaggs DL, Bishop GA, Pace JL, Ibrahim DA, Wren TA, Barzdukas A. Chronic lack of sleep is associated with increased sports injuries in adolescent athletes. https://www.ncbi.nlm.nih.gov/pubmed/25028798 Accessed on 7 October 2018
  8. Schwarz1W.Graham1F.Li1M.Locke2J.Peever1 Sleep deprivation impairs functional muscle recovery following injury https://www.sciencedirect.com/science/article/pii/S1389945713018534#! Accessed on 7 October 2018
  9. Hsieh MJ1,2, Liu HT1,3,4, Wang CN5, Huang HY1, Lin Y1, Ko YS2, Wang JS6, Chang VH7, Pang JS8,9. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. https://www.ncbi.nlm.nih.gov/pubmed/27847966 Accessed on 7 October 2018
  10. Tonglie Huang,1,* Kuo Zhang,2,* Lijuan Sun,3 Xiaochang Xue,1 Cun Zhang,1 Zhen Shu,1 Nan Mu,1 Jintao Gu,1 Wangqian Zhang,1 Yukun Wang,1 Yingqi Zhang,1 and Wei Zhang1 Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425239/ Accessed on 7 October 2018
  11. Chang CH1, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. https://www.ncbi.nlm.nih.gov/pubmed/21030672 Accessed on 7 October 2018
  12. Cerovecki T1, Bojanic I, Brcic L, Radic B, Vukoja I, Seiwerth S, Sikiric P. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. https://www.ncbi.nlm.nih.gov/pubmed/20225319 Accessed on 7 October 2018

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