Cardarine is considered one of the most effective endurance supplements on the market. It’s also ideal for athletes looking to increase their metabolism and burn fat more efficiently, as it targets the androgen receptors that stimulate glucose to the muscles.

Cardarine Box JumpCardarine (also known as GW 501516) was originally developed by Ligand Pharmaceuticals and British pharmaceutical company GlaxoSmithKline Plc. It was designed to prevent prostate and breast tumors and later to increase HDL and reduce LDL cholesterol in the body.

Cardarine is an effective SARM for

  • Cutting
  • Increased Endurance

Cardarine is classified as a PPAR (Peroxisome Proliferator-Activated Receptor), so is not a traditional SARMS, though it’s properties and characteristics are identical to a SARM. Early research at The Robarts Research Institute in Ontario, Canada showed Cardarine to be an effective PPAR and have a positive effect on insulin resistance. [1]

One research study reported that Cardarine caused cancer in rats. [2] What is important to highlight from this study is that the rats were given 240x what is considered a normal dose. They were also given it every day for two years, which is much longer than the 4-12-week cycle that is recommended.

Cardarine Crossfit Woman Tire

Cardarine Benefits

Cardarine is a specific SARM and can be used for;


The cutting phase involves lowering your body fat and is an important phase for those that for example, have the abs there, though they are hidden under a little spare tire.

To cut body fat, you need to create a calorie deficit. It’s remembering that we all require different amounts of calories. Our demands for energy based on the food we consume differs depending on our age, weight, height and activity levels. Research has shown that cutting should be done with small or moderate deficits (i.e. around -500 kcal) to avoid loss of muscle mass. [3]

The quality of calories consumed during this phase is really important. This means eating the right balance of protein, fats and carbohydrates. Research at McMaster University in Hamilton, Canada has shown that eating a high-protein diet during cutting phase is important to preserve muscle mass. [4]

Cardarine Diet for Cutting

It’s also important that you are providing your muscles with a strong stimulus via your training. If you just eat a calorie deficit without resistance training and focus more on cardio training, you may lose more muscle than intended. Research at The University of North Carolina has shown strength training is important while cutting to avoid muscle loss. [5]

What makes Cardarine such an effective supplement during the cutting phase is its ability to raise the natural metabolic rate. This is because Cardarine targets the androgen receptors that stimulate glucose to the muscles. Research at The University of Queensland in Australia has shown Cardarine promotes fat burning in muscle while increasing metabolism. [6]

Furthermore, research has shown that PPAR’s like Cardarine regulate glucose metabolism and insulin sensitivity. This is because they allow the body to use fat as energy, which allow athletes to train intensely and be more efficient at losing body fat. [7]

Increased Endurance

Cardarine is considered among users as “the ultimate endurance enhancing supplement.” This is due to its ability to allow athletes to train at high levels of intensity during their workouts and break through plateaus. It also allows them to recover faster, which is why it has gained the reputation it has.

One of the most prominent animal studies done with Cardarine showed that mice using it showed exceptional stamina and could run twice the length of other mice. [8]

Cardarine targets and enhances the ability of muscles to use energy more efficiently, which allows athletes to achieve a higher level of performance without putting excessive demands on the body compared to those who are not using it.

Cardarine Endurance

This is because Cardarine helps to prevent oxidative damage on the heart. Researchers at The Mayo Clinic College of Medicine in Rochester, Minnesota found that Cardarine increased bioavailability of a precursor to nitric oxide, which helps to improve blood flow and therefore allow the body to function more optimally. [9]

Cardarine Side Effects

There have been no reported side effects with Cardarine in the last 20 years.

Cardarine Dosage

10-20 mg per day is a sufficient dose. 10 mg a day is aimed for endurance, and the higher dosage is better for fat loss, though when starting out begin with a lower dose of 5 mg and adjust accordingly depending on how your body responds to it.

It has a 16-24-hour half-life, so you can take a 10 mg dosage once per day, or if taking 20 mg per day then I recommend splitting your dose into two, taking one dose every 10-12 hours.

Cardarine Dosage

It is recommended to be used for 4-12-week cycles with 4-6 week break cycles.

Final Thoughts

SARMS are such an innovative and popular supplement amongst athletes, bodybuilders, powerlifters and cross fitters. Cardarine is an upgraded, safer and alternative version to anabolic steroids. It’s formulated and created to target specific androgen receptors in specific areas in the body without the side effects commonly associated with its predecessor.

Disclaimer: SARMs are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.


  1. Bojic LA1, Burke AC, Chhoker SS, Telford DE, Sutherland BG, Edwards JY, Sawyez CG, Tirona RG, Yin H, Pickering JG, Huff MW. Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice. Accessed on 28 August 2018
  2. Ruth L. Stephen, Mattias C. U. Gustafsson, Morag Jarvis, Roger Tatoud, Barry R. Marshall, Deborah Knight, Ewa Ehrenborg, Adrian L. Harris, C. Roland Wolf and Colin N. A. Palmer Activation of Peroxisome Proliferator-Activated Receptor δ Stimulates the Proliferation of Human Breast and Prostate Cancer Cell Lines Accessed 28 August 2018
  3. Eric R Helms, Alan A Aragon and Peter J Fitschen Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation Accessed on 20 August 2018
  4. Stuart M. Phillips A Brief Review of Higher Dietary Protein Diets in Weight Loss: A Focus on Athletes Accessed on 20 August 2018
  5. Eric T Trexler,1 Abbie E Smith-Ryan,1 and Layne E Norton2 Metabolic adaptation to weight loss: implications for the athlete Accessed on 20 August 2018
  6. Uwe Dressel Tamara L. Allen  Jyotsna B. Pippal  Paul R. Rohde  Patrick Lau George E. O. Muscat The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells Accessed on 28 August 2018
  7. Chih-Hao Lee,*† Peter Olson,†‡§ Andrea Hevener,¶ Isaac Mehl,‡§ Ling-Wa Chong,‡ Jerrold M. Olefsky,¶ Frank J. Gonzalez,∥ Jungyeob Ham,** Heonjoong Kang,** Jeffrey M. Peters,†† and Ronald M. Evans‡ PPARδ regulates glucose metabolism and insulin sensitivity Accessed on 28 August 2018
  8. Chen W1, Gao R2, Xie X1, Zheng Z1, Li H2, Li S1, Dong F2, Wang L1. A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. Accessed on 28 August 2018
  9. Anantha Vijay R.SanthanamabLivius V.d’UscioabTongrongHeabZvonimir S.Katusic PPARδ agonist GW501516 prevents uncoupling of endothelial nitric oxide synthase in cerebral microvessels of hph-1 mice! Accessed on 28 August 2018

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