CJC 1295-DAC

CJC-1295 DAC has the ability to extend the effects of Human Growth Hormone (HGH or just Growth Hormone – GH) in the body, which is why it is a popular choice for athletes. It has a positive effect on enhancing muscle growth, fat loss and recovery when combined with the right training protocol.

CJC-1295 DAC is a long-acting analogue of Growth Hormone Releasing Hormone (GHRH), which naturally stimulates the body’s production of GH.

CJC-1295 DAC Benefits

CJC-1295 benefits include;

  • Increase Muscle Strength,
  • Increase Lean Muscle Mass
  • Lose Body Fat
  • Improved Recovery and Repair

CJC 1295-DAC History

CJC 1295 (also known as modified GRF 1-29) was created by Canadian Medical Biotechnology company ConjuChem and is a modified version of the very first twenty-nine amino acids of GHRH.

ConjuChem also created DAC (Drug Affinity Complex) technology to generate more GH pulses and extend the half-life of CJC 1295.

CJC 1295 can increases Human Growth Hormone (HGH) levels by 2 to 10-fold

DAC binds to the protein albumin, which allows it to stay for longer in the body, extending the effects of the peptide it comes with, such as CJC 1295.

CJC 1295 consists of a chain of 30 amino acids, whereas with a DAC formula, there’s a chain of 44 amino acids. This is what makes it more effective than CJC 1295 without DAC at promoting muscle growth, and aiding recovery, which is why its such a popular choice with athletes.

Research has shown that CJC 1295 can increases GH levels by 2 to 10-fold for six days or longer and Insulin Growth Factor 1 (IGF-1) levels by 1.5 to 3-fold for 9 to 11 days. [1]

CJC-1295 DAC Growth Hormone Increase

CJC 1295-DAC Benefits

The benefits for any athlete using CJC 1295-DAC is due to its’ ability to stimulate Growth Hormone.

Best Peptide Guide Pituitary Gland
Pituitary Gland

Growth Hormone is produced in the brain by the pituitary gland. It plays an important role in the growth of cells, bones, muscles, and organs throughout the body.

Growth Hormone  along with other hormones such as estrogen, progesterone, testosterone, and DHEA, are known to decline in production with age. GH levels are highest in growing children and peak at around age 20. From the age of 30, this production slows down by around 14 per cent every decade. This means that by the time you reach 40 your body is secreting around 40 per cent compared to when you were 20. By age 60 this number is down to 25 per cent.

The decline of GH is known as somatopause and normally falls in line with the female menopause and the so-called male andropause.

Growth hormone is secreted in a pulsatile fashion and is stimulated by exercise, nutrition and sleep. Experts estimate that as much as 75 per cent of human growth hormone is released during sleep. [2]

Predominantly during the first period of Stage 3 Non-REM deep sleep stage, which happens about an hour after you first fall asleep. Actually, research at The University of Chicago found that 70% of the HGH pulses during sleep coincide with Non-REM, deep sleep, and the amount of GH secreted during these pulses correlates with the amount of deep Sleep. [3]

Exercise

When it comes to exercise research shows that the time of day does not alter the GH response to training. [4]

However, intensity can impact GH response. Research has shown that high-intensity exercise for a minimum of 10 minutes elicits the biggest stimulus to the secretion of HGH. [5]

CJC-1295 DAC Workout Intensity

Human Growth Hormone also accelerates lipolysis, the breakdown of Fats. Researchers at Yonsei University College of Medicine in Seoul, Korea found that GH treatment caused a 1.6-fold increase in weight loss, with the greatest loss being visceral fat, the fat stored around the stomach and organs, which is harder to lose. Furthermore, lean body mass was gained compared to a placebo group who lost. [6]

What makes CJC 1295-DAC so effective is DAC’s ability to prevent the production of DPP-4 (Dipeptidyl Peptidase-4), an enzyme associated with cellular death. This then extends the half-life and the bioavailability of CJC 1295. Research has shown that 90% of CJC 1295 was stabilised with DAC after subcutaneous injection. [1]

Nutrition

Growth Hormone works in conjunction with other hormones to keep you in optimal health.

CJC-1295 DAC DietElevated levels of cortisol, glucose and even GH itself decrease GH production and secretion.

This is why fasting is a great stimulus for GH production. Research has shown that during fasting there is an GH spike early in the morning, but there is regular secretion throughout the day as well. The study at The University of Virginia showed a 5-fold increase in GH in response to a two day fast. [7]

CJC 1295-DAC Side effects

The only reported side effects are itching, pain, redness, and soreness at the injection point,

CJC 1295-DAC Dosage

*Popularly Recommended Dosing Guidelines for CJC-1295 DAC

CJC-1295 DAC has a long half-life of approximately eight days, so you only need one injection per week. The recommended dose is 500-1000mcg per week for a maximum of 4-6 months. Always start with a lower dose to see how the body responds.

Final Thoughts

CJC-1295 DAC Final Thoughts

Compared to steroids and testosterone, which offer users a faster burn regarding results, peptides like CJC 1295-DAC offers more of a medium burn, though without the potentially uncomfortable side effects that come with the former. This is why if your goal is to increase muscle mass, burn body fat, and improve muscle recovery then peptides are the best option.

Disclaimer: Peptide Hormones are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.

References

  1. Teichman SL1, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. https://www.ncbi.nlm.nih.gov/pubmed/16352683 Accessed on 7 October 2018
  2. Godfrey RJ1, Madgwick Z, Whyte GP. The exercise-induced growth hormone response in athletes. https://www.ncbi.nlm.nih.gov/pubmed/12797841 Accessed on 12 September 2018
  3. Van Cauter E1, Plat L. Physiology of growth hormone secretion during sleep. https://www.ncbi.nlm.nih.gov/pubmed/8627466 Accessed on 12 September 2018
  4. Jill A. Kanaley Judy Y. Weltman  Karen S. Pieper  Arthur Weltman  Mark L. Hartman Cortisol and Growth Hormone Responses to Exercise at Different Times of Day https://academic.oup.com/jcem/article/86/6/2881/2849394 Accessed on 12 September 2018
  5. Godfrey RJ1, Madgwick Z, Whyte GP. The exercise-induced growth hormone response in athletes. https://www.ncbi.nlm.nih.gov/pubmed/12797841 Accessed on 12 September 2018
  6. Kim KR1, Nam SY, Song YD, Lim SK, Lee HC, Huh KB. Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults. https://www.ncbi.nlm.nih.gov/pubmed/10352397 Accessed on 12 September 2018
  7. Hartman ML1, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E, Thorner MO. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. https://www.ncbi.nlm.nih.gov/pubmed/1548337 Accessed on 12 September 2018

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