FTTP

Weight and fat loss are what every athlete is looking to optimize at some point during their training protocol. The peptide FTTP (Fat Targeted Proapoptotic Peptide) has been shown to be one of the best effective supplements for targeting white fat cells and allowing you to achieve rapid results.

FTTP (also known as Fat Targeted Proapoptotic Peptide and Adipotide) is known as a peptidomimetic, which are small protein-like chains designed to mimic a peptide. FTTP is designed to promote fat loss by focusing on white fat cells. Research at The University of Texas showed FTTP effectiveness at targeting white fat cells vasculature system to promote fat loss. [1]

FTTP benefits include;

  • Decreased Body Fat
  • Weight Loss

FTTP Abs

FTTP History

FTTP was developed by Dr Wadih Arap and his wife Renata Pasqualini PhD at The Rutgers New Jersey Medical School, as a treatment to fight obesity.

FTTP’s chemical structure is designed to bind to two specific protein receptors in the body, Prohibitin (PHB) and Annexin A2 (ANX2), which are specific to blood vessels supplying white fat cells.

Research has shown that white fat cells hypotrophy (cell degeneration) due to reduced fatty acid uptake when these two proteins are inhibited. [2]

This is why research has shown that FTTP can cause rapid weight loss. [3]

FTTP Benefits

When it comes to losing weight or dropping body fat is important to understand the two types of fat that we have. Firstly, we have white adipose tissue (WAT), which is often considered the bad guy because it’s found around your stomach, hips and legs, the areas that you struggle to lose weight from. WAT is fat storing and is our largest energy reserve in the body and acts as a thermal insulator for our internal organs, though its role is much more important than this. It is also a major hormonal organ, producing one form of estrogen as well as leptin, our hormone that helps to regulate energy balance by inhibiting hunger. It also has growth hormone, insulin, adrenaline and cortisol receptors.

FTTP White Adipose Tissue

We then have brown adipose tissue (BAT), which is primarily found around your collar bones, sternum, neck, and upper back. Its function is to burn calories to generate heat, also known as thermogenesis. Until 2009, scientists thought BAT was only found in babies to keep them warm, though it is now known that adults have a small amount and can increase what they have. What makes brown fat so important for weight and fat loss is that It can generate heat by burning white fat.

When we gain weight, it’s generally due to the expansion of our white fat cells, which in number is determined by your genes. Dieting can shrink fat cells but not eliminate them, which is why people can gain weight back so quickly. Research at The Karolinska Institute in Stockholm, Sweden has shown that approximately 10% of fat cells are renewed each year, though the number does not change. [4]

FTTP does not have any effect on the brown adipose tissue, though stimulating and increasing brown fat will enhance your ability to lose body fat and reduce WAT cell size with FTTP. Two ways of doing this are through exercise and cold thermogenesis.

The positive effects of exercise on the body have long been known, but understanding how it effects brown fat is still relatively new. Research at the Ohio State University Wexner Medical Centre found that levels of the fat controlling hormone 12, 13-diHOME were increased post-exercise. They’re released by brown adipose tissue (BAT) and trigger muscles to increase their uptake and metabolism of fatty acids, but not glucose. [5]

FTTP HIIT

When it comes to exercise, research shows that High-intensity interval training (HIIT) was more effective than moderate-intensity continuous training (MICT) over a 12-week period at reducing abdominal visceral fat. [6]

Furthermore, researchers at The University of New South Wales in Sydney, Australia found that High intensity interval training (HIIT), three times a week for 15 weeks was significantly more effective than steady-state exercise at reducing total body fat, and subcutaneous leg and trunk fat. [7]

FTTP Cold ThermogenesisWhat exercise does, is to create a ‘browning’ effect on WAT, due to a hormone called irisin, which converts WAT to have similar characteristics as BAT. Therefore, creating more thermogenic effective FAT to be burned to help you drop body fat. [8]

Whereas BAT creates thermogenesis, taking a cold shower or ice bath is cold-thermogenesis and will effectively recruit more of our BAT to help you lose fat. Research has shown that ten days of a cold acclimation protocol will increase BAT in the body. [9]

FTTP Side effects

Studies have shown that the only possible side effects that come with FTTP use are dehydration and possible kidney failure.

FTTP Dosage

*Popularly Recommended Dosing Guidelines for FTTP

Recommended daily dose is 1-5 mg/once per day. Always start with the lowest dose and adjust accordingly depending on response.

FTTP Lean Gains

Final Thoughts

Compared to steroids and testosterone, which offer users a faster burn regarding results, peptides like FTTP offers more of a medium burn, though without the potentially uncomfortable side effects that come with the former. This is why if your goal is to increase muscle mass, burn body fat, and improve muscle recovery then peptides are the best option.

Disclaimer: Peptide Hormones are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.

References

  1. Kolonin MG1, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. https://www.ncbi.nlm.nih.gov/pubmed/15133506 Accessed on 29 September 2018
  2. Ahmad Salameh,1 Alexes C. Daquinag,1 Daniela I. Staquicini,2 Zhiqiang An,1 Katherine A. Hajjar,3 Renata Pasqualini,2 Wadih Arap,corresponding author4 and Mikhail G. Kolonin1 Prohibitin/annexin 2 interaction regulates fatty acid transport in adipose tissue https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959783/ Accessed on 29 September 2018
  3. Kirstin F. Barnhart,1,2 Dawn R. Christianson,1,3 Patrick W. Hanley,2 Wouter H. P. Driessen,1,3 Bruce J. Bernacky,2 Wallace B. Baze,2 Sijin Wen,4 Mei Tian,5 Jingfei Ma,6 Mikhail G. Kolonin,7 Pradip K. Saha,8,9 Kim-Anh Do,4 James F. Hulvat,10 Juri G. Gelovani,5 Lawrence Chan,8,9 Wadih Arap,1,3,5,*† and Renata Pasqualini1,3,5 A Peptidomimetic Targeting White Fat Causes Weight Loss and Improved Insulin Resistance in Obese Monkeys https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666164/ Accessed on 29 September 2018
  4. Spalding KL1, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O, Blomqvist L, Hoffstedt J, Näslund E, Britton T, Concha H, Hassan M, Rydén M, Frisén J, Arner P. Dynamics of fat cell turnover in humans. https://www.ncbi.nlm.nih.gov/pubmed/18454136 Accessed on 29 September 2018
  5. Kristin I. Stanford, Matthew D. Lynes, Hirokazu Takahashi, Yu-Hua Tseng, Paul M. Coen, Laurie J. Goodyear 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake https://www.cell.com/cell-metabolism/fulltext/S1550-4131(18)30241-9 Accessed on 29 September 2018
  6. Haifeng Zhang, 1 , 2 Tom K. Tong, 3 Weifeng Qiu, 4 Xu Zhang, 1 Shi Zhou, 5 Yang Liu, 1 and Yuxiu He 1 Comparable Effects of High-Intensity Interval Training and Prolonged Continuous Exercise Training on Abdominal Visceral Fat Reduction in Obese Young Women https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237463/ Accessed on 29 September 2018
  7. E G Trapp, D J Chisholm, J Freund & S H Boutcher The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women https://www.nature.com/articles/0803781 Accessed on 29 September 2018
  8. Rodrigues KCDC1, Pereira RM1, de Campos TDP1, de Moura RF2, da Silva ASR3, Cintra DE4, Ropelle ER1,5, Pauli JR1,5, de Araújo MB6, de Moura LP1,5,7. The Role of Physical Exercise to Improve the Browning of White Adipose Tissue via POMC Neurons. https://www.ncbi.nlm.nih.gov/pubmed/29643769 Accessed on 29 September 2018
  9. Anouk A.J.J. van der Lans,1 Joris Hoeks,1 Boudewijn Brans,2 Guy H.E.J. Vijgen,1,3 Mariëlle G.W. Visser,2 Maarten J. Vosselman,1 Jan Hansen,1 Johanna A. Jörgensen,1 Jun Wu,4 Felix M. Mottaghy,2,5 Patrick Schrauwen,1 and Wouter D. van Marken Lichtenbelt1 Cold acclimation recruits human brown fat and increases nonshivering thermogenesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726172/ Accessed on 2018

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