GHRP-2

GHRP-2 is one of the most effective peptides on the market for stimulating Human Growth Hormone (HGH) production and improving an athlete’s ability to increase lean muscle mass, reduce body fat and enhance athletic performance and recovery.

Effectiveness of GHRP 2

GHRP-2 (also known as KP 102 and Pralmorelin) is designed to increase the natural production of Growth Hormone (GH). Research at The Obihiro University of Agriculture and Veterinary Medicine in Japan highlighted the effectiveness of GHRP-2 to stimulate GH release and enhance growth performance. [1]

GHRP-6 Benefits include;

  • Increased Production of Human Growth Hormone (HGH)
  • Improved Recovery
  • Increased IGF-1 Production
  • Increases Lean Muscle Mass
  • Decreased Body Fat

GHRP-2 History

Soon after the discovery of Growth Hormone Releasing Hormone (GHRH) in the early 80’s, they discovered Growth Hormone Releasing Peptides (GHRP), specifically GHRP-6. GHRP-2 is a 2nd generation GHRP discovered soon after GHRP-6. GHRP’s activate different receptors in the brain than GHRH’s, though acted synergistically with GHRH to trigger the natural release of Growth Hormone by the pituitary.

Best Peptide Guide Pituitary Gland
Pituitary Gland

GHRP-2 is more effective than its big brother GHRP-6 at releasing Growth Hormone by the pituitary. In a clinical trial at The University of Washington, GHRP-2 showed significant increases in HGH levels. [2]

GHRP-2 Benefits

The benefits for any athlete using GHRP-2 is due to its’ ability to stimulate Growth Hormone.

Growth Hormone (also known as Somatotropin) is produced in the brain by the pituitary gland. It affects the growth of cells, bones, muscles, and organs throughout the body.

Growth Hormone along with other hormones such as estrogen, progesterone, testosterone, and DHEA, are known to decline in production with age. GH levels are highest in growing children and peak at around age 20. From the age of 30, this production slows down by around 14 per cent every decade. This means that by the time you reach 40 your body is secreting around 40 per cent compared to when you were 20. By age 60 this number is down to 25 per cent.

The decline of GH is known as somatopause and normally falls in line with the female menopause and the so-called male andropause.

Growth hormone is secreted in a pulsatile fashion and is stimulated by exercise, nutrition and sleep. Experts estimate that as much as 75 per cent of the human growth hormone is released during sleep. [3]

GHRP 2 GH Released During Sleep

Predominantly, GH is produced during the first period of Stage 3 Non-REM deep sleep stage, which happens about an hour after you first fall asleep. Actually, research at The University of Chicago found that 70% of the HGH pulses during sleep coincide with Non-REM, deep sleep, and the amount of GH secreted during these pulses correlates with the amount of deep Sleep. [4]

Exercise

When it comes to exercise research shows that the time of day does not alter the GH response to training. [5]

However, intensity can impact GH response. Research has shown that high-intensity exercise for a minimum of 10 minutes elicits the biggest stimulus to the secretion of HGH. [6]

Growth Hormone also accelerates lipolysis, the breakdown of Fats. Researchers at Yonsei University College of Medicine in Seoul, Korea found that GH treatment caused a 1.6-fold increase in weight loss, with the greatest loss being visceral fat, the fat stored around the stomach and organs, which is harder to lose. Furthermore, lean body mass was gained compared to a placebo group who lost. [7]

HGH Fragment 176-191 visceral fat

Research at The Sichuan Agricultural University in China has shown that GHRP-2 accelerates growth performance and up-regulates the protein synthesis pathways, GH, and IGF-1 secretion. This is why it is such an effective peptide for athletes looking to increase lean muscle mass and reduce body fat. [8]

Nutrition

Human Growth Hormone works in conjunction with other hormones to keep you in optimal health.

Elevated levels of cortisol, glucose and even HGH itself decrease HGH production and secretion.

This is why fasting is a great stimulus for HGH production. Research has shown that during fasting there is an HGH spike early in the morning, but there is regular secretion throughout the day as well. The study at The University of Virginia showed a 5-fold increase in HGH in response to a two day fast. [9]

GHRP 2 Fasting for GH Levels

GHRP-2 potent effects make it an effective supplement to use to help athletes recover from injuries. Research at Tulane University in New Orleans showed that GHRP-2 was effective at reducing oxidative stress, which is a natural part of intense training sessions and can impact the recovery process. [10]

GHRP-2 Side effects

It is similar to GHRP-6 in its ability to increase of cortisol (stress hormone), prolactin (a hormone decreasing sexual desire) and aldosterone (hormone that promotes water retention) levels and due to the better GH secretion effectiveness, it can increase these levels more than GHRP-6.

Cortisol Stress Hormone
Cortisol (stress hormone)

GHRP-2 Dosage

*Popularly Recommended Dosing Guidelines for GHRP-2

It is recommended to take 100-300mcg, 1-2 time per day. Start with a lower dosage and increase according to response.

GHRP-2 is dependent on glucose, specifically when blood sugar levels are low. So must be taken before a meal or 2 hours after a meal.

Final Thoughts

GHRP 2 Final Thoughts

Compared to steroids and testosterone, which offer users a faster burn regarding results, peptides like GHRP-2 offers more of a medium burn, though without the potentially uncomfortable side effects that come with the former. This is why if your goal is to increase muscle mass, burn body fat, and improve muscle recovery then peptides are the best option.

Disclaimer: Peptide Hormones are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.

References

  1. Phung LT1, Inoue H, Nou V, Lee HG, Vega RA, Matsunaga N, Hidaka S, Kuwayama H, Hidari H. The effects of growth hormone-releasing peptide-2 (GHRP-2) on the release of growth hormone and growth performance in swine. https://www.ncbi.nlm.nih.gov/pubmed/10793268 Accessed on 7 October 2018
  2. Pihoker C1, Kearns GL, French D, Bowers CY. Pharmacokinetics and pharmacodynamics of growth hormone-releasing peptide-2: a phase I study in children. https://www.ncbi.nlm.nih.gov/pubmed/9543135 Accessed on 7 October 2018
  3. Godfrey RJ1, Madgwick Z, Whyte GP. The exercise-induced growth hormone response in athletes. https://www.ncbi.nlm.nih.gov/pubmed/12797841 Accessed on 12 September 2018
  4. Van Cauter E1, Plat L. Physiology of growth hormone secretion during sleep. https://www.ncbi.nlm.nih.gov/pubmed/8627466 Accessed on 12 September 2018
  5. Jill A. Kanaley Judy Y. Weltman  Karen S. Pieper  Arthur Weltman  Mark L. Hartman Cortisol and Growth Hormone Responses to Exercise at Different Times of Day https://academic.oup.com/jcem/article/86/6/2881/2849394 Accessed on 12 September 2018
  6. Godfrey RJ1, Madgwick Z, Whyte GP. The exercise-induced growth hormone response in athletes. https://www.ncbi.nlm.nih.gov/pubmed/12797841 Accessed on 12 September 2018
  7. Kim KR1, Nam SY, Song YD, Lim SK, Lee HC, Huh KB. Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults. https://www.ncbi.nlm.nih.gov/pubmed/10352397 Accessed on 12 September 2018
  8. Rui Hu, Zhisheng Wang , Quanhui Peng, Huawei Zou, Hongze Wang, Xiaoqiang Yu, Xiaoping Jing, Yixin Wang, Binghai Cao, Shanke Bao, Wenhua Zhang, Suonan Zhao, Hanzhong Ji, Xiangying Kong, Quanxi Niu Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149461 Accessed on 7 October 2018
  9. Hartman ML1, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E, Thorner MO. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. https://www.ncbi.nlm.nih.gov/pubmed/1548337 Accessed on 12 September 2018
  10. Jane S. Titterington, Sergiy Sukhanov, Yusuke Higashi, Charlotte Vaughn, Cyril Bowers, and Patrice Delafontaine Growth Hormone-Releasing Peptide-2 Suppresses Vascular Oxidative Stress in ApoE−/− Mice But Does Not Reduce Atherosclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795722/ Accessed on 7 October 2018

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