HCG (Human Chorionic Gonadotropin)

 

Human Chorionic Gonadotropin (HCG) is a good peptide for stimulating testosterone production, which will enhance muscle growth and fat loss abilities. It’s also a great addition to those using steroids as it counteracts the common side effects.

Testosterone is an Anabolic HormoneHuman Chorionic Gonadotropin (HCG) is a naturally occurring peptide hormone produced by the embryo and placenta during pregnancy. HCG is structurally similar to and binds to the same receptors in the body as Leutenizing Hormone (LH), which stimulates the Leydig cells in male testes to produce testosterone. Research at The University of Washington showed that a very low dose of HCG significantly influenced testosterone levels. [1]

GHRP-6 Benefits include;

  • Increased Testosterone Levels
  • Improved Muscle Growth
  • Reduced Body Fat

HCG History

It was originally thought that the pituitary gland in the brain produced HCG, though in 1930 American Reproductive Endocrinologist Georgeanna Jones discovered that it was actually manufactured by the placenta.

Although known as the ‘pregnancy hormone’ HCG is a safer alternative for men looking to increase testosterone levels. Research has shown that HCG should be used rather than testosterone therapy. [2]

HCG Medical Study

In 1954, British Physician Albert Simeons proposed that along with an ultra-low-calorie diet (500 calories), HCG injections could be an effective weight loss tool. The HCG diet (also known as the Pounds and Inches Diet) became a popular choice among those seeking a quick fix, though over the year’s popularity declined.

No clinical trials were ever done to support the claims and research at The University of Stellenbosch in South Africa was one of a few studies that showed that weight loss achieved following the HCG diet was actually due to the drastic calorie restriction. [3]

HCG Benefits

The benefits for any athlete using HCG is due to its’ ability to stimulate Testosterone production.

Testosterone’s journey started in 1889 when 72-year-old Mauritian Physiologist and Neurologist Dr Charles Brown-Sequard created the “Elixir of Life” a concoction of blood, semen, and testicular fluid he had extracted from the testicles of dogs and guinea pigs. It wasn’t until 1935 that it would be named as ‘Testosterone’ by Swiss Scientists Ernest Laqueur who isolated it from bull testes. During the same year, it was chemically synthesised independently by German Biochemist Aldolf Butenandt and Croatian-Swiss Scientist Leopold Ruzicka.

HCG and Testosterone

Testosterone levels are highest during adolescence and peak during our early 20’s. By the time we reach the age of 30, testosterone levels start to decline. The decrease is roughly 1 per cent per year so that by your 40’s and 50’s testosterone levels can be low.

HCG and Testosterone While You SleepThe majority of our daily testosterone release occurs during sleep. [4]

There is also a short spike in testosterone levels after exercise, though the intensity of exercise can impact this. Short-term intense exercise, as well as longer moderate intensity exercise, can increase testosterone levels. Whereas, research at The University of North Carolina has shown that prolonged intense exercise can contribute to a lowering of testosterone. [5]

Two hormones that are important for the production of testosterone are

  • Luteinizing hormone (LH), which helps to regulate the testes’ production of testosterone, and converts androstenedione to testosterone.
  • Follicle stimulating hormone (FSH), which controls the production of sperm in the testicles, so together with LH they are needed to maintain healthy levels of testosterone.

HCG works by stimulating the pituitary gland to release FSH and LH, which stimulate the testosterone production. This is why HCG is a popular option with steroid users as it helps to negate the common side effects of steroid use such as testicle shrinkage.

HCG Fights Testicle Shrinkage
HCG Fights Testicle Shrinkage

Testosterone is a key hormonal driver for those looking for optimal results from their diet and training. Research at The University of Rochester School of Medicine and Dentistry showed that testosterone influences muscle growth by stimulating protein synthesis. [6]

Research also shows that testosterone is effective at reducing body fat. [7]

Although the mechanisms behind this are not fully understood, research at The Charles R. Drew University of Medicine and Science found that fluctuations in testosterone had a significant effect on body fat percentage. Participants whose baseline levels were dropped by half showed a 36% increase in fat mass. [8]

Furthermore, research at The University of California showed that testosterone is associated with decreased visceral fat and increased insulin sensitivity. [9]

HGH Fragment 176-191 visceral fat

This is why HCG is a great option for those athletes looking to increase the natural production of testosterone as the research continues to show that HCG helps to increase the levels of testosterone in the body. [10]

HCG Side effects

The primary possible side effects of HCG will be similar to the side effects most commonly associated with high levels of testosterone, predominantly those of an estrogenic nature, such as sexual dysfunction, loss of muscle, increased abdominal fat and depression.

HCG Dosage

*Popularly Recommended Dosing Guidelines for HCG

It has a half-life of about 3-4 days. For a steroid user using HCG while on cycle, it is recommended to uses dose of no higher than 250 IU every 4-5 days, though checking with a doctor or medical practitioner for personal dosage would be highly recommended.

Final Thoughts

HCG For Muscle

Compared to steroids and testosterone, which offer users a faster burn regarding results, peptides like HCG offers more of a medium burn, though without the potentially uncomfortable side effects that come with the former. This is why if your goal is to increase muscle mass, burn body fat, and improve muscle recovery then peptides are the best option.

Disclaimer: Peptide Hormones are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.

References

  1. Y. Roth, S. T. Page, K. Lin, B. D. Anawalt, A. M. Matsumoto, C. N. Snyder, B. T. Marck, W. J. Bremner, and J. K. Amory Dose-Dependent Increase in Intratesticular Testosterone by Very Low-Dose Human Chorionic Gonadotropin in Normal Men with Experimental Gonadotropin Deficiency https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913032/ Accessed on 14 October 2018
  2. Eric M.Lo1Katherine M.Rodriguez1Alexander W.PastuszakMD, PhD23MohitKheraMD, MBA, MPH3 Alternatives to Testosterone Therapy: A Review https://www.sciencedirect.com/science/article/pii/S2050052117301221 Accessed on 14 October 2018
  3. Bosch B1, Venter I, Stewart RI, Bertram SR. Human chorionic gonadotrophin and weight loss. A double-blind, placebo-controlled trial. https://www.ncbi.nlm.nih.gov/pubmed/2405506 Accessed on 14 October 2018
  4. Axelsson J1, Ingre M, Akerstedt T, Holmbäck U. Effects of acutely displaced sleep on testosterone. https://www.ncbi.nlm.nih.gov/pubmed/15914523 Accessed on 14 October 2018
  5. Kaye K. Brownlee,1,* Alex W. Moore,1,* and Anthony C. Hackney1,2,Relationship Between Circulating Cortisol and Testosterone: Influence of Physical Exercise https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880087/ Accessed on 14 October 2018
  6. Griggs RC1, Kingston W, Jozefowicz RF, Herr BE, Forbes G, Halliday D. Effect of testosterone on muscle mass and muscle protein synthesis. https://www.ncbi.nlm.nih.gov/pubmed/2917954 Accessed on 14 October 2018
  7. Mark Ng Tang Fui,1,2 Luke A. Prendergast,1,3 Philippe Dupuis,1,2 Manjri Raval,2 Boyd J. Strauss,4 Jeffrey D. Zajac,1,2 and Mathis Grossmann1,2 Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054608/ Accessed on 14 October 2018
  8. Bhasin S1. Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression. https://www.ncbi.nlm.nih.gov/pubmed/12942389 Accessed on 14 October 2018
  9. Shalender Bhasin Effects of Testosterone Administration on Fat Distribution, Insulin Sensitivity, and Atherosclerosis Progression https://academic.oup.com/cid/article/37/Supplement_2/S142/335512 Accessed on 14 October 2018
  10. Lindsey E. Crosnoe,1 Ethan Grober,2 Dana Ohl,3 and Edward D. Kim1 Exogenous testosterone: a preventable cause of male infertility https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708215/ Accessed on 14 October 2018

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