HGH Fragment 176-191

When it comes to weight loss and dropping body fat, there are few contenders on the market to compete with HGH Fragment 176-191. It is considered one of the safest and best peptide supplements to use by any serious athlete looking to optimize their results from an effective nutrition and training protocol.

Compared to standard HGH it is considered to be 12.5 times stronger for weight loss.

HGH Fragment 176-191 (Also known as AOD-9401) is a modified form of the tail end of Human Growth Hormone (HGH) molecule. This part of the molecule known as the C terminal region, which constitutes less than 10% of the total size of the HGH molecule is the fat-reducing part. Compared to standard HGH it is considered to be 12.5 times stronger for weight loss.

Furthermore, researchers at Monash University in Australia showed HGH Fragment 176-191 ability to induce weight loss.[1]

HGH Fragment 176-191 Induce Weight Loss

HGH Fragment 176-191 benefits include;

  • Decreased Body Fat
  • Weight Loss

HGH Fragment 176-191 History

HGH Fragment 176-191 is developed by Australian Biotechnology company Metabolic Pharmaceuticals Limited. It was designed to mimic the way Human Growth Hormone (HGH) regulates fat metabolism. Research has shown that although it behaves like HGH it does not cause high blood sugar levels (Hyperglycemia), which can be associated with HGH. [2]

HGH Fragment 176-191 Benefits

The benefits for any athlete using HGH Fragment 176-191 is its ability to mimic the weight loss attributes of Human Growth Hormone (HGH).

Pituitary Gland
Pituitary Gland

Human Growth Hormone (also known as HGH and Somatotropin) is produced in the brain by the pituitary gland. It influences the growth of cells, bones, muscles, and organs throughout the body.

Growth Hormone along with other hormones such as estrogen, progesterone, testosterone, and DHEA, are known to decline in production with age. HGH levels are highest in growing children and peak at around age 20. From the age of 30, this production slows down by around 14 per cent every decade. This means that by the time you reach 40 your body is secreting around 40 per cent compared to when you were 20. By age 60 this number is down to 25 per cent.

The decline of HGH is known as somatopause and normally falls in line with the female menopause and the so-called male andropause.

Human growth hormone (HGH) is secreted in a pulsatile fashion and is stimulated by exercise, nutrition and sleep. Experts estimate that as much as 75 per cent of human growth hormone is released during sleep. [3]

HGH Fragment 176-191 Anabolic Sleep

Predominantly during the first period of Stage 3 Non-REM deep sleep stage, which happens about an hour after you first fall asleep. Actually, research at The University of Chicago found that 70% of the HGH pulses during sleep coincide with Non-REM, deep sleep, and the amount of HGH secreted during these pulses correlates with the amount of deep Sleep. [4]

Exercise

When it comes to exercise research shows that the time of day does not alter the HGH response to training. [5]

However, intensity can impact HGH response. Research has shown that high-intensity exercise for a minimum of 10 minutes elicits the biggest stimulus to the secretion of HGH. [6]

Human Growth Hormone (HGH) also accelerates lipolysis, the breakdown of Fats. Researchers at Yonsei University College of Medicine in Seoul, Korea found that HGH treatment caused a 1.6-fold increase in weight loss, with the greatest loss being visceral fat, the fat stored around the stomach and organs, which is harder to lose. Furthermore, lean body mass was gained compared to a placebo group who lost. [7]

HGH Fragment 176-191 visceral fat

Nutrition

Human Growth Hormone (HGH) works in conjunction with other hormones to keep you in optimal health.

Elevated levels of cortisol, glucose and even HGH itself decrease HGH production and secretion.

HGH Fragment 176-191 FastingThis is why fasting is a great stimulus for HGH production. Research has shown that during fasting there is an HGH spike early in the morning, but there is natural secretion throughout the day as well. The study at The University of Virginia showed a 5-fold increase in HGH in response to a two day fast. [8]

Studies on the benefits of HGH Fragment 176-191 date back to the 1970’s. Research showed then that HGH Fragment 176-191 significantly reduced insulin sensitivity, which enhances your ability to lose weight. [9]

This is due to HGH fragment 176-191 ability to stimulate the breakdown of fats (Lipolysis) and inhibits other compounds from being converted to fat (Lipogenesis). In a 12-week randomised phase 2b clinical trial, participants using HGH Fragment 176-191 lost an average of 2.6 kg, compared to 0.8 kg in the placebo group. [10]

HGH Frag 176-191 Side effects

No negative side effects have been noted in research and clinical trials.

Possible sides effects may include irritation or swelling of the skin at the injection site.

HGH Frag 176-191 Dosage

*Popularly Recommended Dosing Guidelines for GHG Fragment 176-191

HGH Fragment 176-191 can be administered 1-2 times per day with twice daily producing optimal results. If once per day, it should be taken 30-60min before breakfast. If twice per day, the second dose should be taken before bed and a few hours after the day’s last meal. 250-500mcg per day is the most common dosing range with 500mcg being the most common. 500mcg per day should produce a significant fat loss in most individuals.

Final Thoughts

HGH Fragment 176-191 Female Weight loss

Compared to steroids and testosterone, which offer users a faster burn regarding results, peptides like HGH Fragment 176-191 offers more of a medium burn, though without the potentially uncomfortable side effects that come with the former. This is why if your goal is to increase muscle mass, burn body fat, and improve muscle recovery then peptides are the best option.

Disclaimer: Peptide Hormones are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.

References

  1. Heffernan M1, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. https://www.ncbi.nlm.nih.gov/pubmed/11713213 Accessed on 19 September 2018
  2. Wu Z1, Ng FM. Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone. https://www.ncbi.nlm.nih.gov/pubmed/8358331 Accessed on 19 September 2018
  3. Godfrey RJ1, Madgwick Z, Whyte GP. The exercise-induced growth hormone response in athletes. https://www.ncbi.nlm.nih.gov/pubmed/12797841 Accessed on 12 September 2018
  4. Van Cauter E1, Plat L. Physiology of growth hormone secretion during sleep. https://www.ncbi.nlm.nih.gov/pubmed/8627466 Accessed on 12 September 2018
  5. Jill A. Kanaley Judy Y. Weltman  Karen S. Pieper  Arthur Weltman  Mark L. Hartman Cortisol and Growth Hormone Responses to Exercise at Different Times of Day https://academic.oup.com/jcem/article/86/6/2881/2849394 Accessed on 12 September 2018
  6. Godfrey RJ1, Madgwick Z, Whyte GP. The exercise-induced growth hormone response in athletes. https://www.ncbi.nlm.nih.gov/pubmed/12797841 Accessed on 12 September 2018
  7. Kim KR1, Nam SY, Song YD, Lim SK, Lee HC, Huh KB. Low-dose growth hormone treatment with diet restriction accelerates body fat loss, exerts anabolic effect and improves growth hormone secretory dysfunction in obese adults. https://www.ncbi.nlm.nih.gov/pubmed/10352397 Accessed on 12 September 2018
  8. Hartman ML1, Veldhuis JD, Johnson ML, Lee MM, Alberti KG, Samojlik E, Thorner MO. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men. https://www.ncbi.nlm.nih.gov/pubmed/1548337 Accessed on 12 September 2018
  9. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. https://www.ncbi.nlm.nih.gov/pubmed/645904 Accessed on 19 September 2018
  10. Obesity drug codenamed AOD9604 highly successful in trials https://www.news-medical.net/news/2004/12/16/6878.aspx Accessed on 19 September 2018

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