Myostatin HMP

Myostatin HMP is an effective peptide for improving lean muscle mass and dropping body fat. It’s ability to inhibit myostatin, which restricts muscle growth makes it a popular choice among athletes looking to complement their diet and training protocol.

Myostatin HMP is a myostatin inhibitor. Research at The Mayo Clinic has shown that when myostatin is inhibited there is increased muscle growth and improved brown adipose tissue, which is important for burning calories and dropping body fat. [1]

Myostatin HMP Benefits

Myostatin HMP Benefits include;

  • Increased Lean Muscle Mass
  • Reduced Body Fat
  • Faster Injury Recovery

Myostatin HMP History

The Myostatin (also known as Growth Factor 8 and GDF-8) gene was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron, although its existence can be traced back to 1807. At the time British farmer Henry Culley noticed that cattle missing a particular gene looked excessively muscular compared with other cattle. This was then confirmed by researchers in 1969 highlighting that ‘Bovine Muscular Hypertrophy’ was exactly what Henry Culley’s reported his cattle had suffered from. [2]

Myostatin is known as a chalone, a substance that is secreted by the cells in the body to suppress excessive growth. Research at The Johns Hopkins University School of Medicine showed that myostatin plays an important role in regulating muscle growth. [3]

Peptide Testosterone and HGH

Myostatin HMP Benefits

Myostatin’s role is to regulate muscle homeostasis by inhibiting protein synthesis. Although much of the research on myostatin has been done on animals, there was a case study reported in 2004 of an infant born with a myostatin gene mutation. The infant showed superior muscle growth and strength at seven months old and by age 4.5 was able to hold 2, 3kg dumbbells with arms out straight. [4]

HMP (Human Myostatin Propeptide) binds to the myostatin receptor and therefore inhibits it from affecting muscle growth. Research at The German Sports University in Cologne showed that HMP was stable and effective for both men and women. [5]

Bodybuilding Muscle Fibers

Furthermore, research showed that myostatin HMP significantly increased muscle fibre size and muscle mass. [6]

Myostatin levels increase with age, which coincides with muscle loss. According to research at The University of Michigan.

“A gradual loss of muscle fibres begins at approximately 50 years of age and continues such that by 80 years of age, approximately 50% of the fibres are lost from the limb muscles that have been studied…. “

Furthermore “performance declines after approximately 40 years of age, with peak levels of performance decreased by approximately 50% by 80 years of age.” [7]

Exercise plays an important role when it comes to myostatin. Research shows that myostatin levels in muscle decrease post aerobic training. [8]

This effect also happens as a result of strength training. Research at The University of Pittsburgh showed that heavy strength training reduced myostatin production. [9]

Myostatin HMP and Age

Furthermore, research has shown that a combination of exercise while taking a myostatin inhibitor may significantly improve physical function and whole-body metabolism. [10]

This decrease in myostatin has a carry-over to injuries and recovery. Research at The Medical College of Georgia showed that blocking myostatin signalling to an injured bone using myostatin HMP improves fracture healing and enhances muscle regeneration. [11]

Myostatin HMP Side effects

Reported side effects are increased the risk of injury due to increased stress on the muscle fibres.

Myostatin HMP Dosage

*Popularly Recommended Dosing Guidelines for Myostatin-HMP

The recommended dosage is 10-25mcg, twice a day. Start with a lower dose and increase according to response.

Final Thoughts

Myostatin HMP for Muscle

Compared to steroids and testosterone, which offer users a faster burn regarding results, peptides like Myostatin HMP offers more of a medium burn, though without the potentially uncomfortable side effects that come with the former. This is why if your goal is to increase muscle mass, burn body fat, and improve muscle recovery then peptides are the best option.

Disclaimer: Peptide Hormones are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.

References

  1. Lebrasseur NK1. Building muscle, browning fat and preventing obesity by inhibiting myostatin. https://www.ncbi.nlm.nih.gov/pubmed/22057197 Accessed on 14 October 2018
  2. Ashmore CR, Robinson DW. Hereditary muscular hypertrophy in the bovine. I. Histological and biochemical characterization. https://www.ncbi.nlm.nih.gov/pubmed/5355105 Accessed on 14 October 2018
  3. Lee SJ1. Regulation of muscle mass by myostatin. https://www.ncbi.nlm.nih.gov/pubmed/15473835 Accessed on 14 October 2018
  4. Markus Schuelke, M.D., Kathryn R. Wagner, M.D., Ph.D., Leslie E. Stolz, Ph.D., Christoph Hübner, M.D., Thomas Riebel, M.D., Wolfgang Kömen, M.D., Thomas Braun, M.D., Ph.D., James F. Tobin, Ph.D., and Se-Jin Lee, M.D., Ph.D. Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child https://www.nejm.org/doi/full/10.1056/NEJMoa040933?query=recirc_curatedRelated_article Accessed on 14 October 2018
  5. Mosler S1, Geisler S, Hengevoss J, Schiffer T, Piechotta M, Adler M, Diel P. Modulation of follistatin and myostatin propeptide by anabolic steroids and gender. https://www.ncbi.nlm.nih.gov/pubmed/23559411 Accessed on 14 October 2018
  6. Phonepasong Arounleut,1 Peter Bialek,2 Li-Fang Liang,3 Sunil Upadhyay,1 Sadanand Fulzele,1 Maribeth Johnson,1 Mohammed Elsalanty,1 Carlos M. Isales,1 and Mark W. Hamrick1,* A Myostatin Inhibitor (Propeptide-Fc) Increases Muscle Mass and Muscle Fiber Size in Aged Mice but Does not Increase Bone Density or Bone Strength https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930487/ Accessed on 14 October 2018
  7. Faulkner JA1, Larkin LM, Claflin DR, Brooks SV. Age-related changes in the structure and function of skeletal muscles. https://www.ncbi.nlm.nih.gov/pubmed/17880359 Accessed on 14 October 2018
  8. Dustin S. Hittel,1 Michelle Axelson,1 Neha Sarna,1 Jane Shearer,1 Kim M. Huffman,2 and William E. Kraus2 Myostatin Decreases with Aerobic Exercise and Associates with Insulin Resistance https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975387/ Accessed on 14 October 2018
  9. Roth SM1, Martel GF, Ferrell RE, Metter EJ, Hurley BF, Rogers MA. Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication. https://www.ncbi.nlm.nih.gov/pubmed/12773702 Accessed on 14 October 2018
  10. Nathan K. LeBrasseur Teresa M. Schelhorn Barbara L. Bernardo Patricia G. Cosgrove Paula M. Loria Thomas A. Brown Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice https://academic.oup.com/biomedgerontology/article/64A/9/940/557704 Accessed on 14 October 2018
  11. Hamrick MW1, Arounleut P, Kellum E, Cain M, Immel D, Liang LF. Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury. https://www.ncbi.nlm.nih.gov/pubmed/20173658 Accessed on 14 October 2018

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