PEG MGF is considered the best variant of Insulin-like Growth Factor (IGF) for local muscle growth on the market. Its ability to stimulate the release of Mechano Growth Factor (MGF) into the system to initiates muscle growth and repair is why it’s so popular with athletes.

PEG MGF (Also known as Pegylated Mechano Growth Factor) is a spliced variant of the IGF-1 (insulin-like growth factor-1). It’s a combination of MGF (Mechano Growth Factor) which plays an integral role post-exercise to help build new muscle and repair damaged muscle. Together with PEG (Polyethylene Glycol) which provides stability for MGF to exert its effects, they are creating an innovative supplement for athletes. Researchers at The University of Vienna in Austria found that MGF was effective in improving athletic performance and treating injuries. [1]

PEG MGF Benefits

PEG MGF Benefits include;

  • Improved Athletic Performance
  • Increases Lean Muscle Mass
  • Improved Recovery

PEG MGF History

PEG MGF is developed by Swiss Pharmaceutical company Nanox Biotechnology and is considered the best variant of Insulin-like Growth Factor (IGF) for local muscle growth on the market. Research at The Virginia Commonwealth University showed how effective MGF is at eliciting muscle growth. [2]

PEG MGF Benefits

Mechano Growth Factor (also known as MGF and IGF-1Ec) is a splice variant of IGF-1 and was only discovered in 1996. MGF is produced locally within the muscles, whereas IGF-1 is manufactured in the liver mediated by Growth Hormone (GH).

Using MGF alone poses two restrictions. The first is its inability to travel through the body to other areas of the body and secondly once secreted by the liver it remains in the bloodstream for about 5-7 minutes before it breaks down.

PEG MGF In Bloodstream

This is where the PEGylating of MGF enhances its benefits to be more effective by allowing the MGF molecule to be carried through the bloodstream without breaking down. The Polyethylene Glycol (PEG) attaches itself to the MGF acting as a shell to protect and support it around the body allowing its half-life to change from 5-7 minutes to a few hours.

MGF’s role is to increase stem cell count in the muscle, which stimulates muscle growth and recovery and also increase protein synthesis. It is produced naturally as a result of muscle breakdown from resistance training. Research has shown that MGF can increase the weight of muscle fibre by 20 per cent within two weeks, making it more potent at muscle growth than IGF-1. [3]

Furthermore, research at The Royal Free and University College Medical School in London, UK found that in response to exercise and/or damage, MGF is expressed locally and that it activates the muscle stem cell pool and increases the anabolic effects. [4]

During an intense training session, you are breaking muscle tissue down, and your muscles experience small micro-tears resulting in increased blood flow to the muscles. This is when the real growth and repair process starts to happen, as in response to the breakdown MGF stimulates the production of muscle satellite (stem) cells.

PEG MGF Intense Training

In response to the release of MGF, the liver releases IGF-1 to stimulate protein synthesis, which stimulates muscle growth and repair. Researchers at Huazhong University of Science and Technology in China found that MGF protects from connective tissue damage and promotes healing. [5]

Furthermore, research at The Mayo Clinic College of Medicine found MGF to be twice as effective than IGF-1 in protecting neurons.[6]

The ability of MGF to impact older injuries is also extremely powerful. Research has shown that degeneration of cartilage from Osteoarthritis can be delayed by MGF.[7]

IGF has such strong receptor affinity, if you dose with them both at the same time, the effectiveness of MGF will just be wasted.

PEG-MGF Side effects

The only reported side effects are temporary irritation, such as redness and itching at the injection site.

Injection Site

PEG-MGF Dosage

*Popularly Recommended Dosing Guidelines for PEG-MGF

The recommended dosage is 200-400mcg per day. Start with a lower dose and increase according to response.

IGF has such strong receptor affinity, so if you are looking to use an IGF-1 stimulating peptide with PEG-MGF ensure that you get your timing right as stimulating IGF-1 levels too early will affect the effectiveness of MGF.

Final Thoughts

PEG MGF Final Thoughts

Compared to steroids and testosterone, which offer users a faster burn regarding results, peptides like PEG MGF offer more of a medium burn, though without the potentially uncomfortable side effects that come with the former. This is why if your goal is to increase muscle mass, burn body fat, and improve muscle recovery then peptides are the best option.

Disclaimer: Peptide Hormones are banned by WADA and most other global sporting organisation for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.


  1. Bachl N1, Derman W, Engebretsen L, Goldspink G, Kinzlbauer M, Tschan H, Volpi P, Venter D, Wessner B Therapeutic use of growth factors in the musculoskeletal system in sports-related injuries. Accessed on 19 September 2018
  2. Chao Li, Kent Vu, Krystina Hazelgrove, and John F. Kuemmerle Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn’s disease and smooth muscle hypertrophy Accessed on 19 September 2018
  3. Vivian Owino Shi Yu Yang  Geoffrey Goldspink Age‐related loss of skeletal muscle function and the inability to express the autocrine form of insulin‐like growth factor‐1 (MGF) in response to mechanical overload Accessed on 19 September 2018
  4. G Goldspink and P Jakeman Research on mechano growth factor: its potential for optimising physical training as well as misuse in doping Accessed on 19 September 2018
  5. Jing X1, Ye Y1, Bao Y1, Zhang J1, Huang J1, Wang R1, Guo J1, Guo F2. Mechano-growth factor protects against mechanical overload-induced damage and promotes migration of growth plate chondrocytes through RhoA/YAP pathway. Accessed on 19 September 2018
  6. Jason J. Tang, Jewel L. Podratz, Miranda Lange, Heidi J. Scrable^, Mi-Hyeon Jang and Anthony J. Windebank Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the ageing mouse brain Accessed on 19 September 2018
  7. Song, Yang & Xu, Kang & Yu, Can & Dong, Lili & Chen, Peixing & Lv, Yonggang & Chiang, Martin & Li, Lin-Hao & Liu, Wanqian & Yang, Li. The use of mechano growth factor to prevent cartilage degeneration in knee osteoarthritis Accessed on 19 September 2018

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