Have you heard people talking about SARMS? 

Are you wondering what SARMs are and why people are taking them?  Are you wondering why Congress wants to BAN them?

Keep reading…

Are you looking to take your muscle development to another level?

We are all looking to perform better and achieve better results with our training, whether it’s to gain muscle, look more shredded or become the king of endurance sports.

To break through plateaus and get quicker results, many have taken to the use of steroids.

Steroids have done exactly what they said they would do, help people achieve results by increasing testosterone, which then increases protein synthesis in cells, allowing them to be more effective at building muscle and burning fat.

That’s the anabolic state that you need to get the results you want.  However…

Dont Do Steroids SM

Though, it also comes with androgenic side effects, because steroids interact with your liver, prostate, heart, and your sex organs.

This makes you more susceptible to symptoms such as testicle shrinkage in men and clitoral enlargement in women, hair loss, acne, decreased sperm count and depression in both.

This is why there has been a growing interest in SARMs (Selective Androgen Receptor Modulators).

SARMs are are synthetic drugs designed to stimulate receptors in your body’s tissue to help stimulate muscle and bone growth, maintain muscle mass, as well as improve strength and stamina while decreasing body fat.

 What do SARMs do?

Scientists working on SARMs in the labSARMs have been part of a controversial debate that goes back to the early 90s when they were first introduced into mainstream science. Their journey actually goes back to the 1940s when steroidal SARMs were being used for medical use to treat multiple diseases including cancer, hypogonadism, osteoporosis, and a number of other diseases that affect muscle and bone wasting.

This is because they are considered a healthier alternative to testosterone replacement therapy. Though they also came with side effects such as puffy sensitive nipples in men, decreased libido, and damage to the liver and kidneys.

It wasn’t until the early 1990s that scientists started creating non-steroidal versions of SARMs by making them protein based.

The difference is that non-steroidal SARMs are more targeted in unlocking specific cells in the body.

They’re designed to stimulate the androgen (testosterone) receptors in muscle and bone cells, without affecting the other cells of the body. Whereas steroidal SARMs act more like a master key and can unlock every cell in the body, hence the side effects.

This is why non-steroidal SARMs has become a major player in the bodybuilding, powerlifting and sports arenas.

See, steroids have an anabolic-to-androgenic ratio of 1:1. Whereas SARMs boast an anabolic-to-androgenic ratio starting at 3:1 and going as amazingly high as 90:1. This breakthrough in scientific technology continues to suggest SARMs is the future of helping you stay in an anabolic state.

SAMRs athlete with barbells

What’s great about SARMs is that its side effects are minimal, so you don’t have to worry about any negative effects.

When used responsibly, and in 99.9% of cases, users will not have any side effects.

What confirms this is that current research has so far agreed with that conclusion.

For example, research has shown that SARMS improves physical function and bone health with no negative side effects on the prostate and your cardiovascular health [1].

The best part is that many SARMs are taken orally, which means you no longer have to bear painful injections and worry about abscess formation and needle cleanliness and hygiene.

 Painful Injections

The Benefits of SARMS

SARMS do not break down into “unwanted” molecules that can have an effect on other hormones such as Estrogen and Dihydrotestosterone (DHT).

Furthermore, SARMS do not convert into 5-a reductase, an enzyme that converts Testosterone into DHT that is the primary “driver” of many side effects of steroids.

This means you can expect benefits such as

  • Muscle loss prevention (during the cutting phase)
  • Lean muscle development
  • Increased muscle strength

Research published in the Asian Journal of Andrology showed that subjects who used SARMs increased muscle strength 20x more than those in the placebo group. Furthermore, subjects continued to gain strength and size in muscle tissue for up to 5 months [2].

  • Increased muscle size
  • Faster injury recovery
  • Joint healing abilities

The use and benefits of SARMs continue to show amazing results that to go beyond the realms of fitness and sports use.

SARMs athlete curling

Research by biopharmaceutical company GTx inc looking at the prevention and treatment of muscle wasting associated with cancer, SARMs were effective in phase 3 clinical trials. One, in particular, Ostarine, which is one of the most widely used SARMs, was found to stimulate better physical function and increases in lean body mass across several populations along with a lower hazard ratio for survival in cancer patients [3].

You will notice that SARMs sellers will include disclaimers such as “for lab research purposes only” and “not for human consumption.”

So they are legal, as long as you buy them “for research purposes only.” This is because if laws change, they will not compromise government guidelines.

Update: The bill called the Selective Androgen Receptor Modulators Control Act of 2018, sponsored by Sen. Hatch, Orrin G. [R-UT] and co-sponsored by Sen. Whitehouse, Sheldon [D-RI], has only been introduced as of May 2018.  This bill is not a law as of yet so you can still buy SARMs as of the time of this articles publishing.  We will update the article as this situation evolves.

 Why Not Just Take Testosterone?

As SARMs are designed to stimulate testosterone receptors, wouldn’t it just be easier to just take testosterone I hear you ask?

Yes, you can take testosterone either by injecting it or absorbing it through their skin as a topical cream or gel, though like steroids is also comes with dangerous side effects, especially with higher doses.

This includes symptoms such as:

  • Breast tenderness in women and increased breast tissue in men
  • Increase in sexual drive or absent sexual desire altogether
  • Trembling and numbness in the hands and feet
  • Swelling and tenderness at the injection site
  • Anxiety and Depression
  • Facial hair in women and increased body hair in men
  • Baldness in men
  • Sleep Apnea
  • Chest pain and pressure
  • Nausea and vomiting
  • Painful Erections

Furthermore, excessive testosterone use can also increase calcium in the blood, which can lead to liver damage.

Testosterone Molecule

In a 2014 study[4], which looked at traditional testosterone treatments as well as safer alternative forms of therapeutic treatments such as SARMs (RAD 140) to treat neurodegenerative diseases confirmed that a SARM is effective in addressing diseases such as Alzheimer’s, which can be aggravated by low testosterone levels.

Our natural testosterone levels drop during the normal ageing process, and as a result of this our risk for prostate cancer grows significantly as well.

Testosterone Declines

Testosterone treatments and injections come with more severe side effects compared with SARMs and this would make this the preferred option.

There are a number of SARMs in either clinical (human) trials or pre-clinical (animal) trials.

So let’s dive in and take you on a journey into the 11 main players and why you should consider using them to help you whether you are looking for fat loss, muscle growth or performance enhancement.

S4 Andarine BannerS4 (Andarine)

Andarine started out with promising results as a male contraceptive and showed promising results like a decrease in spermatogenesis (sperm production) and huge boosts in male libido.

However, when researchers began experimenting on mice they discovered interesting findings of how this first generation SARM affected castrated lab mice.

They found that it was very selective in increasing the production of muscle mass and calcium for bone density.

Andarine is by far the most versatile SARM ever created, it has become the most analysed and investigated SARM so far. After the discovery of its anabolic potential, the primary purpose of Andarine aimed to develop an alternative treatment for age-related muscle wasting, and osteoporosis.

When given to castrated rats for 4 weeks, for example, Andarine increased muscle weight as markedly as DHT [5].

Furthermore, in human studies with Andarine, it has shown increases of up to 3lbs in lean body mass in less than 90 days with no increase in exercise or change in diet [6]. An unintended side effect, or let’s say, an added benefit, is that there was also a decrease in body fat.

Andarine is a great option for cutting cycles since it has the ability to promote drastic amounts of fat loss while holding onto precious muscle. Research with female rats whose ovaries have been removed, apart from improving bone strength, also decreased body fat [7].

If you are looking to increase muscle mass, while dropping body fat, then Andarine is one to have in the locker.

*Popularly Recommended Dosing Guidelines for S4 (Andarine)

The recommended dosage is 25-50 mg 3x per day, though when starting out begin with a lower dose of 5-10 mg and adjust accordingly depending on how your body responds to it.

You can use doses up to 50-75mg, as its half-life is only 4-6 hours, this is why it is recommended to split dosages throughout the day. It can be used in cycles up to 6-8 weeks, with 2-4 days off in between cycles.

RAD140 Testolone Banner

RAD140 (Testolone)

Testolone is currently being developed by pharmaceutical company Radius.

Its initial discovery was originally published in 2010, which means studies are limited. However, initial studies have been highly promising for building muscle without the side effects.

Discovered via an Internal Discovery Program, Testolone is actually being developed for the treatment of breast cancer and muscle wasting in postmenopausal women.

In vitro studies have shown that Testolone inhibits the growth of AR/ER+ breast cancer cells [8]. As a result of these studies, the first human clinical trials were brought forward and are currently being done.

What makes this an exciting SARM is that like other SARMs such as LGD4033 (Ligandrol) or S4 (Andarine), Testolone produces similar results to testosterone but without the side effects.

Testolone’s number one benefit is its ability to increase lean tissue without increasing fat. In fact, during initial studies done on monkeys [9], they found that in just 28 days there were average weight gains of more than 10% without any adverse side effects traditionally related to testosterone.

they found that in just 28 days there were average weight gains of more than 10% without any adverse side effects traditionally related to testosterone

Furthermore, this gain in lean tissue may enhance speed, stamina and endurance during high-intensity workouts (think about your HIIT workouts). So if you are looking to work out longer, harder and get better results every time you hit the gym, then this is definitely one SARM worth considering.

*Popularly Recommended Dosing Guidelines for RAD140 (Testolone)

It is recommended to use dosages of between 20-30 mg for best results, though when starting out begin with a lower dose of 5-10 mg and adjust accordingly depending on how your body responds to it. Females are advised to start at 5mg per day with an upper limit of no more than 10mg per day.

It has a half-life of 24-36 hours and should be used for no longer than 12 weeks cycles with breaks of 4-12 weeks depending on the cycle period before starting a new cycle.­­­­

GW 501516 Cardarine Banner

GW 501516 (Cardarine)

While it’s not technically a SARM, Cardarine is often labelled as a SARM. Its ability to help you push past plateaus and feel energized longer make its results as impressive as those that you will experience from SARMs, which is why I have added it to the list.

Whereas a SARM binds to androgen receptors, Cardarine binds to PPARδ (Peroxisome proliferator-activated receptor delta) receptors, which play an important role in lipid absorption, so fewer calories are stored as adipose tissue (fat cells) while you are on it.

This makes it a great option for cutting down, while still holding onto hard earned muscle while you are in a calorie deficit. This is because, like some SARMs, it also activates AMPK (AMP-activated protein kinase), which is responsible for stimulating muscle glucose uptake, skeletal muscle tissue, and oxidizing fatty acids

Cardarine has also been shown by researchers in Philadelphia to increase HDL Cholesterol [10] by up to 79% while decreasing LDL Cholesterol [11].

Cardarine was originally developed in the 1990s to prevent and cure tumours in the breasts, prostate and colon. It was then in the early 2000s that Studies by researchers at the Institute for Molecular Bioscience at Queensland University in Australia found that it and other PPAR agonists have also been able to stop metabolic disorders such as obesity and diabetes [12].

As research continued to grow, athletes quickly caught on as it became known as the “the ultimate endurance enhancing supplement.” This was due to its potent endurance increasing ability, which has been confirmed in animal studies [13].  Where it is reported that mice had a faster recovery process of muscle tissue and neurotransmitters.

Cardarine for endurance

The mice lost weight even when eating a diet high in fat.

Its ability to enhance recovery coupled with no harmful side effects found in the past 20 years, makes Cardarine a staple in many athlete’s cycles.

Now, something worth mentioning is that there was study on Cardarine reported that is caused cancer in rats [14]. Now if we take that at face value, it can be quite concerning, though when you look further into the study you realize that the rats were given 240x the normal dose and taken every day for 2 years straight.

If nothing else, this is a good reminder to stick to the recommended dosage guidelines, and when doing your own research ensure that you look into the details, so that you understand it fully because no other study done found a negative correlation between Cardarine and Cancer.

*Popularly Recommended Dosing Guidelines for GW 501516 (Cardarine)

10-20 mg per day is a sufficient dose. 10 mg a day is aimed for endurance, and the higher dosage is better for fat loss, though when starting out begin with a lower dose of 5 mg and adjust accordingly depending on how your body responds to it.

It has a 16-24 hour half-life, so you can take a 10 mg dosage once per day, or if taking 20 mg per day then I recommend splitting your dose into two, taking one dose every 10-12 hours.

It is recommended to be used for 4-12 week cycles with 4-6 week break cycles

SR9009 Stenabolic Banner

SR9009 (Stenabolic)

Stenabolic was developed by Dr Thomas Burris at Scripps Research Institute.

Like Cardarine it has a unique ability to promote weight loss and curb increased glucose levels.

Dr Burris first used it to experiment with mice. Within days, the treated mice became leaner, developed larger muscles and had a 50% increase in running ability.

These results have led scientists to believe that Stenabolic can be beneficial in treating people who suffer from illnesses that can limit physical movements such as obesity, COPD (chronic obstructive pulmonary disease) and congestive heart failure.

What makes it so effective and has been shown in research is its ability to bind itself to Rev-erbα [15], which is responsible for lipid and glucose metabolism, and regulating our 24-hour circadian rhythms to maintain homeostasis within the body.

Furthermore, research has shown that activation of Rev-erbα with Stenabolic [16] resulted in enhanced metabolic activity in skeletal muscle tissue in both culture and in mice, which the researchers believed would help stimulate the formation of new mitochondria, which are known as the “power plants” within each of our cells and help to keep our cells young and vibrant.

Stenabolic is not as anabolic as some of the other SARMs, so is a perfect fit for those who are looking to cut or recomp.

It is known as “exercise in a bottle.” Because you can experience the benefits of working out without working out by using it.

Of course, I always recommend using it with training to get optimal results.

*Popularly Recommended Dosing Guidelines for SR9009 (Stenabolic)

The recommended dosage is 10-20 mg per day. When starting out begin with a lower dose of 5 mg and adjust accordingly depending on how your body responds to it

It is safe to consume doses 30-40 mg per day. It is recommended to split larger doses into 6 single doses, which you can take every two to four hours.

It is recommended to cycle Stenabolic on a minimum of 12-week cycles.

MK-2866 Ostarine Banner

MK-2866 (Ostarine)

Ostarine is also known as Enobosarm was created by biopharmaceutical company GTx Inc to avoid and treat muscle wasting.

Ostarine uses its anabolic effects on muscle tissue fully so it’s not only a potential cure for muscle wasting ailments but brings incredible benefits to athletes who not only want to retain lean body mass but also increase it.

It is also effective in reducing recovery times from serious surgery or similar conditions.

With multiple published human trials under its belt, Ostarine is one of the best-studied SARMs.

For example, research has shown that it is effective in improving insulin resistance [17]. When insulin docks onto the muscle cells, it instigates biochemical reactions in the muscle that increase protein synthesis, therefore improving muscle growth.

In addition, insulin also decreases muscle breakdown, which further enhances muscle growth.

Furthermore, in a double-blind, placebo-controlled phase 2 trial [18] by GTx Inc with elderly men and women who took modest doses for 12 weeks grew 3 pounds of muscle and lost a pound of fat. These results were achieved with no changes to diet or exercise.

These effects are also shown in treating people with cancer.

In a phase 2b, double-blind, placebo-controlled study [19], Ostarine treatment was well tolerated and led to significantly improved lean body mass, physical function, and quality of life in men older than 45 years and postmenopausal women with cancer.

*Popularly Recommended Dosing Guidelines for MK-2866 (Ostarine)

Recommended doses are 25-50 mg every 24-36 hours and it can be used for up to 6 months. When starting out begin with a lower dose of 10 mg and adjust accordingly depending on how your body responds to it

For bulking, 25 mg for 4-6 weeks is recommended. For recomping, 12.5-25 mg for 4-8 weeks is recommended. For cutting, 12.5-15 mg for 4-6 weeks.

It has a half-life of 24 hours and it is recommended to take 4 weeks off between cycles

 MK-677 Nutrobal Banner

MK-677 (Nutrobal)

Nutrobal was originally formulated to manage health problems like osteoporosis, obesity and muscle wasting.

It has been shown during clinical trials to promote an increase in lean body mass as it boosts IGF-1 (Insulin-like growth factor 1) levels, which helps to build muscle [20].

Nutrobal is a compound that induces the pituitary gland to increase production of human growth hormone (HGH), which is responsible for functions such as regulating body composition, muscle and bone growth, and sugar and fat metabolism.

The increase in growth hormone levels is due to Nutrobal’s ability to mimic the action of the hormone ghrelin, which is known as the ‘hunger hormone, as it stimulates appetite, by binding to one of the ghrelin receptors (GHSR) in the brain.

Activation of GHSR is what stimulates growth hormone to be released by the brain.

Research at the Centre for the Study of Biological Rhythms in Belgium has shown that it increases growth hormone levels with little or no increase in other hormones, such as cortisol, which can suppress the immune system [21].

The effects of a growth hormone deficiency or a decline in growth hormone from ageing include:

  • Lower bone density
  • Increased body fat
  • Muscle wasting
  • Reduced energy

Research at the Research Centre for Endocrinology and Metabolism in Sweden has shown that in healthy obese men, a two-month treatment with Nutrobal increased lean mass, and transiently increased basal metabolic rate (BMR). [22]

Aside from the increase in your IGF-1 and HGH levels while taking Nutrobal, you can experience many benefits such as:

  • Quicker healing of ligaments, tendons, bones as well as old injuries
  • Build lean muscle mass and achieve better size gains
  • Increase in fat oxidation

One of the other great benefits often reported by users of Nutrobal is an improvement in sleep.

Researchers at the Centre for the Study of Biological Rhythms (CERB) and Laboratory of Experimental Medicine in Belgium investigated the use of Nutrobal for improved sleep in young and older adults. [23]

A group of younger adults took doses at bedtime during three 7-day-long sleep cycles. Whereas a group of older adults participated in two 14-day-long treatments. What was fascinating is that both groups experienced a 50% increase in REM (Rapid Eye Movement) sleep, which is associated with learning new information and maintaining important neural pathways.

*Popularly Recommended Dosing Guidelines for MK-677 (Nutrobal)

The recommended dosage is 5-25mg daily, taken over an 8-10-week cycle. When starting out begin with a lower dose of 5 mg and adjust accordingly depending on how your body responds to it

It has a half-life of 24 hours, so once a day dosing is all that is required. You can safely take up to 25 mg per day, preferably taking 12.5 mg at night and 12.5 mg in the morning. Though for general fat burning and stamina, 10mg is sufficient enough to improve HGH levels and see results.

YK-11 Banner

YK-11

In 2011, Yuichiro Kanno of Toho University published the results of an initial study on YK11, confirming that the rare compound was a SARM. [24]

However, it is considered by many to be what is known as a Myostatin Inhibitor. Myostatins are produced by the cells to inhibit muscle growth, essentially preventing your body from making too much muscle.

YK11’s chemical structure more resembles the chemical structure of DHT than that of a SARM, though again because of its effectiveness it is worth adding to this list.

Most SARMS have limited androgenic side effects, but also lesser anabolic effect when compared to testosterone, which is what makes them a safer choice.

However, When Kanno used muscle cells to test the effects of the SYK11, he found that the muscle cells produce more anabolic factors if exposed to the same dosage of DHT.

This is because YK11 induces muscle cells to increase production of the protein Follistatin, which is a strong Myostatin inhibitor.

The result being that you can achieve significant gains in lean muscle mass that would otherwise be unattainable.

The research on YK11 is still in its infancy, with only studies by Kanno and his team on its effects. A later study in 2013 has shown YK11 to offer benefits such as [25];

  • Lean size gains without water retention
  • Increased muscular fullness and better pumps
  • Muscle hardening
  • No anabolic steroid side effects

What makes YK11 an interesting choice is that it functions via a totally different mechanism than SARMs, Steroids, or HGH, so it will be exciting to see what further research and development reveals?

*Popularly Recommended Dosing Guidelines for YK-11

Recommend dosage is 2-5 mg, twice per day, though there is no set in stone dosing protocol for YK11. When starting out begin with the lowest dose possible and adjust accordingly depending on how your body responds to it

The half-life of YK11 is unknown, so would follow traditional protocol as with other SARMS of 24-36 hours.

LGD 4033 Ligandrol Banner

LGD 4033 (Ligandrol)

Ligandrol was originally discovered by Ligand pharmaceuticals was developed for the treatment of muscle wasting conditions, such as ageing, osteoporosis, muscular dystrophy and cancer, though it is currently under development by Viking Therapeutics as VK5211 in phase 2 clinical trials.

Ligandrol is the strongest orally bioavailable SARM currently on the market. This makes it a popular choice for athletes, powerlifters and bodybuilders as its one of the best options for those looking to reduce body fat and increase lean muscle mass (Recomp).

Ligandrol is the strongest orally bioavailable SARM currently on the market

It is one of the better studied SARMs, as it has been through multiple human trials, with interesting results.

A double-blind, placebo-controlled Phase I clinical trial in 2010 was the first study in humans of Ligandrol, which showed its safety and effectiveness as a SARM for further research. [26]

This led to a placebo-controlled study by Shehzad Basaria at the Boston Medical Center a couple of years with healthy men who took Ligandrol for 21 days saw a significant increase in lean body mass. Results in muscle growth were seen with dosages as low as 1 mg. [27]

What makes Ligandrol a great option is its anti-catabolic activity, which means it prevents the breakdown of hard-earned muscle. Meaning its ability to increase lean muscle mass without increasing fat when bulking.

This is why lean body mass has been reported in some users to increase even during a caloric deficit.

Results from the 21-day study also indicated improved muscle strength and endurance, which is why it is being studied to prevent and treat older individuals recovering from hip fractures. [28]

*Popularly Recommended Dosing Guidelines for LGD 4033 (Ligandrol)

Results can be achieved with doses of 1-5 mg, though dosage should not exceed 10 mg. Females are advised to stick to an upper limit of 5 mg per day. When starting out begin with a lower dose of 1-2 mg and adjust accordingly depending on how your body responds to it

It has a half-life of 24-26 hours and should be used for 4 weeks. It can be tolerated for up to 12 weeks, though it has been reported to lower testosterone levels when used for longer periods, though levels return to normal quickly after stopping. Once your 4 weeks are up, wait at least a month before starting another cycle.

SARMs athlete building huge arms

The latest SARMs on the market

ACP-105 Banner

ACP-105

ACP-105 is the first of 3 of the newer, lesser known and lesser researched SARMs I want to mention.

ACP-105 first appeared in scientific literature in 2009 when a study showed that a relatively low concentration of ACP-105 was more effective than DHT in binding to androgen receptors. [29]

Further research by researchers at Oregon Health and Science University has shown its effect on building lean muscle in mice. [30]

*Popularly Recommended Dosing Guidelines for ACP-105

Dosing for human use is impossible to do without some sort of experimentation being done, and as of now there are no clinical trials done on humans. I would suggest using dosage as per supplier website product recommendation.

AC-262 536 BannerAC-262,536

AC-262,536 is a SARM created by biopharmaceutical company, ACADIA Pharmaceuticals Inc, and is still considered as a research chemical in the field of medicine.

Research has shown that it can improve muscle growth by as much as 66% compared to the introduction of testosterone. [31]

Furthermore, the same study showed that AC-262,536 was 14x less effective on the prostate size compared with testosterone.

*Popularly Recommended Dosing Guidelines AC-262,536

Dosing for human use is impossible to do without some sort of experimentation being done, and as of now there are no clinical trials done on humans. I would suggest using dosage as per supplier website product recommendation.

S23 Banner

S23

S23 is a new SARM developed by Biopharmaceutical Company GTx Inc. developed as a possible male hormonal contraceptive. It has been shown to boost lean muscle mass growth, and bind to the androgen receptor more intensely compared to older SARMs such as Andarine. [32]

*Popularly Recommended Dosing Guidelines for S23

Dosing for human use is impossible to do without some sort of experimentation being done, and as of now there are no clinical trials done on humans. I would suggest using dosage as per supplier website product recommendation.

SARM Stacks

SARMs are often stacked together, which means that you use two or more compounds at the same time during a cycle. The reason why SARMs are stacked together is simple, you want to get the best results possible.

SARMS Stacks

Now, everybody has a different goal they want to achieve. Whether you want to lose body fat, recomp or gain as much lean muscle mass as possible in a short period of time.

Beside those goals some SARMs stacks can be used for recovery from injuries or improving endurance. So here are 3 stacks that are worth trying, though also keep an eye on the market as developers are now creating stack supplements, so that it’s all done for you.

SARM stack for cutting

If you are looking to lose body fat while maintaining muscle mass, and look lean and shredded, then there are a number of SARMs that stack work well together to help you achieve that.

SARM stack for cutting

A good cutting stack would be Andarine with Ostarine or even Cardarine.

SARM stack for bulking

If your goal is to purely gain lean muscle mass in a short period of time then have a play with different SARM stack to see which ones your body responds to, to give you the best results.

SARM stack for bulking

A good bulking stack would be Ligandrol with Testolone or even Nutrobal.

SARM stacks for recomping

Losing body fat whilst adding lean muscle (recomping) at the same time can be quite a slow process when done naturally, though with the right SARMs stack can change your body in a matter of weeks.

SARM stacks for recomping

A good recomp stack would be Ligandrol with Andarine.

Final Thoughts

The research and human trials are showing great promise for SARMs not just for muscle growth, fat loss and improved endurance, but also in preventing muscle wasting and age related illnesses. With little or no side effects associated with them compared to anabolic steroids I believe they are the future of supplementation and will become a standard part of any serious athlete’s protocol.

Remember, SARMS can only do so much for you without diet and exercise. You still have to put the time and effort in if you want to really maximize the results these compounds provide for you.

Disclaimer: SARMs are banned by WADA and most other global sporting organization for both in-competition and out-of-competition use. You should NOT use them if you are competing in any such sanctioned sport as it a prohibited class of anabolic agents. Please check with local doping agencies for the latest information.

*Popularly Recommended Dosing Guidelines are based on study and manufacturer information and are for informational purposes only.  Always consult a doctor and follow manufacturer recommendations when taking any supplement.

 

References

  1. Shalender Bhasin, MD and Ravi Jasuja. Selective Androgen Receptor Modulators (SARMs) as Function Promoting Therapies. US National Library of Medicine National Institutes of Health, 12 May 2009. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907129/. Accessed 19 April 2018.
  1. Matthew Dl O’Connell, and Frederick C W Wu. Androgen effects on skeletal muscle: Implications for the development and management of frailty. ResearchGate, Jan. 2014, https://www.researchgate.net/publication/259882454_Androgen_effects_on_skeletal_muscle_Implications_for_the_development_and_management_of_frailty. Accessed 19 April 2018.
  1. Dalton JT1, Taylor RP, Mohler ML, Steiner MS. Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer. https://www.ncbi.nlm.nih.gov/pubmed/24189892. Accessed 19 April 2018.
  1. Anusha Jayaraman,* Amy Christensen,* V. Alexandra Moser, Rebekah S. Vest, Chris P. Miller, Gary Hattersley, and Christian J. Pike Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959610/ Accessed 19 April 2018.
  1. Hanada K1, Furuya K, Yamamoto N, Nejishima H, Ichikawa K, Nakamura T, Miyakawa M, Amano S, Sumita Y, Oguro N. Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis. https://www.ncbi.nlm.nih.gov/pubmed/14600402. Accessed 19 April 2018.
  1. Chen J1, Kim J, Dalton JT. Discovery and therapeutic promise of selective androgen receptor modulators. https://www.ncbi.nlm.nih.gov/pubmed/15994457. Accessed 19 April 2018.
  1. Kearbey JD1, Gao W, Narayanan R, Fisher SJ, Wu D, Miller DD, Dalton JT. Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats. https://www.ncbi.nlm.nih.gov/pubmed/17063395. Accessed 19 April 2018.
  1. Yu Z1, He S2, Wang D2, Patel HK2, Miller CP2, Brown JL2, Hattersley G2, Saeh JC1 Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. https://www.ncbi.nlm.nih.gov/pubmed/28974548. Accessed 19 April 2018.
  1. Chris P. Miller, *† Maysoun Shomali,† C. Richard Lyttle,† Louis St. L. O’Dea,† Hillary Herendeen,† Kyla Gallacher,† Dottie Paquin,† Dennis R. Compton,‡ Bishwabhusan Sahoo,‡ Sean A. Kerrigan,‡ Matthew S. Burge,‡ Michael Nickels,‡ Jennifer L. Green,‡ John A. Katzenellenbogen,§ Alexei Tchesnokov,∥ and Gary Hattersley Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018048/. Accessed 19 April 2018.
  1. Olson EJ1, Pearce GL, Jones NP, Sprecher DL. Lipid effects of peroxisome proliferator-activated receptor-δ agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. https://www.ncbi.nlm.nih.gov/pubmed/22814748. Accessed 19 April 2018.
  1. Eric J. Olson, Gregory L. Pearce, Nigel P. Jones, Dennis L. Sprecher Lipid Effects of Peroxisome Proliferator-Activated Receptor-Δ Agonist GW501516 in Subjects With Low High-Density Lipoprotein Cholesterol http://atvb.ahajournals.org/content/32/9/2289. Accessed 19 April 2018.
  1. Uwe Dressel Tamara L. Allen Jyotsna B. Pippal Paul R. Rohde Patrick Lau George E. O. Muscat The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells https://academic.oup.com/mend/article/17/12/2477/2747399. Accessed 19 April 2018.
  1. Wei Chen, Rong Gao, Xinni Xie, Zhibing Zheng, Haijing Li, Song Li, Fangting Dong & Lili Wang A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice https://www.nature.com/articles/srep09884. Accessed 19 April 2018.
  1. Ruth L. Stephen, Mattias C. U. Gustafsson, Morag Jarvis, Roger Tatoud, Barry R. Marshall, Deborah Knight, Ewa Ehrenborg, Adrian L. Harris, C. Roland Wolf and Colin N. A. Palmer Activation of Peroxisome Proliferator-Activated Receptor δ Stimulates the Proliferation of Human Breast and Prostate Cancer Cell Lines http://cancerres.aacrjournals.org/content/64/9/3162.full. Accessed 19 April 2018.
  1. Laura A. Solt,1,* Yongjun Wang,1,* Subhashis Banerjee,1 Travis Hughes,1 Douglas J. Kojetin,1 Thomas Lundasen,1 Youseung Shin,2 Jin Liu,1 Michael D. Cameron,2 Romain Noel,2 Seung-Hee Yoo,3 Joseph S. Takahashi,3 Andrew A. Butler,4 Theodore M. Kamenecka,2 and Thomas P. Burris Regulation of Circadian Behavior and Metabolism by Synthetic REV-ERB Agonists https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343186/. Accessed 19 April 2018.
  1. Lore Geldof *, Koen Deventer, Kris Roels, Eva Tudela and Peter Van Eenoo Regulation of Circadian Behavior and Metabolism by Synthetic REV-ERB Agonists mdpi.com/1422-0067/17/10/1676/pdf. Accessed 19 April 2018.
  1. James T. Dalton, Kester G. Barnette, Casey E. Bohl, Michael L. Hancock, Domingo Rodriguez, Shontelle T. Dodson, Ronald A. Morton, and Mitchell S. Steiner The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177038/. Accessed 19 April 2018.
  1. Dalton JT1, Barnette KG, Bohl CE, Hancock ML, Rodriguez D, Dodson ST, Morton RA, Steiner MS. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. https://www.ncbi.nlm.nih.gov/pubmed/22031847. Accessed 19 April 2018.
  1. Jeffrey Crawford, Carla M. M. Prado, Mary Ann Johnston, Richard J. Gralla, Ryan P. Taylor, Michael L. Hancock, and James T. Dalton Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853438/. Accessed 19 April 2018.
  1. Ralf Nass, M.D.,1 Suzan S. Pezzoli, B.A.,1 Mary Clancy Oliveri, M.S.,1 James T. Patrie, M.S.,2 Frank E. Harrell, Jr., Ph.D.,1,3 Jody L. Clasey, Ph.D.,4 Steven B. Heymsfield, M.D.,5 Mark A. Bach, M.D.,5 Mary Lee Vance, M.D.,1 and Michael O. Thorner, M.B., B.S., D.Sc.1 Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757071/. Accessed 19 April 2018.
  1. Copinschi G1, Van Onderbergen A, L’Hermite-Balériaux M, Mendel CM, Caufriez A, Leproult R, Bolognese JA, De Smet M, Thorner MO, Van Cauter E. Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men. https://www.ncbi.nlm.nih.gov/pubmed/8768828. Accessed 19 April 2018.
  1. Svensson J1, Lönn L, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Boseaus I, Sjöström L, Bengtsson BA. Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure. https://www.ncbi.nlm.nih.gov/pubmed/9467542. Accessed 19 April 2018.
  1. Copinschi G1, Leproult R, Van Onderbergen A, Caufriez A, Cole KY, Schilling LM, Mendel CM, De Lepeleire I, Bolognese JA, Van Cauter E. Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. https://www.ncbi.nlm.nih.gov/pubmed/9349662. Accessed 19 April 2018.
  1. Kanno Y1, Hikosaka R, Zhang SY, Inoue Y, Nakahama T, Kato K, Yamaguchi A, Tominaga N, Kohra S, Arizono K, Inouye Y. (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor. https://www.ncbi.nlm.nih.gov/pubmed/21372378. Accessed 19 April 2018.
  1. Kanno Y1, Ota R, Someya K, Kusakabe T, Kato K, Inouye Y. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. https://www.ncbi.nlm.nih.gov/pubmed/23995658. Accessed 19 April 2018.
  1. Ligand Presents First-in-Human Phase I Data on Lead SARM Molecule LGD-4033 at the International Congress of Endocrinology https://www.businesswire.com/news/home/20100329005621/en/Ligand-Presents-First-in-Human-Phase-Data-Lead-SARM. Accessed 19 April 2018.
  1. Shehzad Basaria,1 Lauren Collins,1,* E. Lichar Dillon,2,* Katie Orwoll,1 Thomas W. Storer,1 Renee Miciek,1 Jagadish Ulloor,1 Anqi Zhang,1 Richard Eder,1 Heather Zientek,3 Gilad Gordon,3 Syed Kazmi,3 Melinda Sheffield-Moore,2,* and Shalender Bhasin The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111291/. Accessed 19 April 2018.
  1. VK5211: Selective Androgen Receptor Modulator http://www.vikingtherapeutics.com/pipeline/vk5211/. Accessed 19 April 2018.
  1. Schlienger N1, Lund BW, Pawlas J, Badalassi F, Bertozzi F, Lewinsky R, Fejzic A, Thygesen MB, Tabatabaei A, Bradley SR, Gardell LR, Piu F, Olsson R. Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators. https://www.ncbi.nlm.nih.gov/pubmed/19856921. Accessed 19 April 2018.
  1. Dayger C1, Villasana L, Pfankuch T, Davis M, Raber J. Effects of the SARM ACP-105 on rotorod performance and cued fear conditioning in sham-irradiated and irradiated female mice. https://www.ncbi.nlm.nih.gov/pubmed/21219889. Accessed 19 April 2018.
  1. Piu F1, Gardell LR, Son T, Schlienger N, Lund BW, Schiffer HH, Vanover KE, Davis RE, Olsson R, Bradley SR. Pharmacological characterization of AC-262536, a novel selective androgen receptor modulator. https://www.ncbi.nlm.nih.gov/pubmed/18164613. Accessed 19 April 2018.
  1. Amanda Jones,a Jiyun Chen,a Dong Jin Hwang, Duane D. Miller, and James T. Dalton Preclinical Characterization of a (S)-N-(4-Cyano-3-Trifluoromethyl-Phenyl)-3-(3-Fluoro, 4-Chlorophenoxy)-2-Hydroxy-2-Methyl-Propanamide: A Selective Androgen Receptor Modulator for Hormonal Male Contraception https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630904/. Accessed 19 April 2018.

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